Roles of Prion Protein in Virus Infections.
Identifieur interne : 000959 ( Main/Exploration ); précédent : 000958; suivant : 000960Roles of Prion Protein in Virus Infections.
Auteurs : Suehiro Sakaguchi [Japon] ; Junji Chida [Japon]Source :
- DNA and cell biology [ 1557-7430 ] ; 2018.
Descripteurs français
- KwdFr :
- Activation enzymatique, Animaux, Cellules épithéliales (enzymologie), Cellules épithéliales (immunologie), Cellules épithéliales (virologie), Cuivre (immunologie), Cuivre (métabolisme), Espèces réactives de l'oxygène (immunologie), Espèces réactives de l'oxygène (métabolisme), Facteurs de protection, Infections à Orthomyxoviridae (enzymologie), Infections à Orthomyxoviridae (génétique), Infections à Orthomyxoviridae (immunologie), Infections à Orthomyxoviridae (virologie), Poumon (enzymologie), Poumon (immunologie), Poumon (virologie), Protéines PrPC (génétique), Protéines PrPC (immunologie), Protéines du choc thermique (génétique), Protéines du choc thermique (immunologie), Régulation de l'expression des gènes (immunologie), Souris, Stress oxydatif, Superoxide dismutase-1 (génétique), Superoxide dismutase-1 (immunologie), Virus de la grippe A (pathogénicité), Virus de la grippe A (physiologie).
- MESH :
- enzymologie : Cellules épithéliales, Infections à Orthomyxoviridae, Poumon.
- génétique : Infections à Orthomyxoviridae, Protéines PrPC, Protéines du choc thermique, Superoxide dismutase-1.
- immunologie : Cellules épithéliales, Cuivre, Espèces réactives de l'oxygène, Infections à Orthomyxoviridae, Poumon, Protéines PrPC, Protéines du choc thermique, Régulation de l'expression des gènes, Superoxide dismutase-1.
- métabolisme : Cuivre, Espèces réactives de l'oxygène.
- pathogénicité : Virus de la grippe A.
- physiologie : Virus de la grippe A.
- virologie : Cellules épithéliales, Infections à Orthomyxoviridae, Poumon.
- Activation enzymatique, Animaux, Facteurs de protection, Souris, Stress oxydatif.
English descriptors
- KwdEn :
- Animals, Copper (immunology), Copper (metabolism), Enzyme Activation, Epithelial Cells (enzymology), Epithelial Cells (immunology), Epithelial Cells (virology), Gene Expression Regulation (immunology), Heat-Shock Proteins (genetics), Heat-Shock Proteins (immunology), Influenza A virus (pathogenicity), Influenza A virus (physiology), Lung (enzymology), Lung (immunology), Lung (virology), Mice, Orthomyxoviridae Infections (enzymology), Orthomyxoviridae Infections (genetics), Orthomyxoviridae Infections (immunology), Orthomyxoviridae Infections (virology), Oxidative Stress, PrPC Proteins (genetics), PrPC Proteins (immunology), Protective Factors, Reactive Oxygen Species (immunology), Reactive Oxygen Species (metabolism), Superoxide Dismutase-1 (genetics), Superoxide Dismutase-1 (immunology).
- MESH :
- chemical , genetics : Heat-Shock Proteins, PrPC Proteins, Superoxide Dismutase-1.
- chemical , immunology : Copper, Heat-Shock Proteins, PrPC Proteins, Reactive Oxygen Species, Superoxide Dismutase-1.
- chemical , metabolism : Copper, Reactive Oxygen Species.
- enzymology : Epithelial Cells, Lung, Orthomyxoviridae Infections.
- genetics : Orthomyxoviridae Infections.
- immunology : Epithelial Cells, Gene Expression Regulation, Lung, Orthomyxoviridae Infections.
- pathogenicity : Influenza A virus.
- physiology : Influenza A virus.
- virology : Epithelial Cells, Lung, Orthomyxoviridae Infections.
- Animals, Enzyme Activation, Mice, Oxidative Stress, Protective Factors.
Abstract
The normal cellular prion protein, designated PrPC, is a membrane glycoprotein expressed most abundantly in brains, particularly by neurons, and to a lesser extent in non-neuronal tissues including lungs. Conformational conversion of PrPC into the amyloidogenic isoform is a key pathogenic event in prion diseases. We recently found that PrPC has a protective role against infection with influenza A viruses (IAVs) in mice by reducing reactive oxygen species in the lungs after infection with IAVs. The antioxidative activity of PrPC is probably attributable to its function to activate antioxidative enzyme Cu/Zn-superoxide dismutase, or SOD1, through regulating Cu content in lungs infected with IAVs. Oxidative stress could play a pivotal role in the pathogenesis of a wide range of viral infections. Here, we introduce our and others' studies on the role of PrPC in viral infections, and raise the attractive possibility that PrPC might be a novel target molecule for development of antioxidative therapeutics against not only IAV infection but also other viral infections.
DOI: 10.1089/dna.2018.4402
PubMed: 30222366
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000244
- to stream PubMed, to step Curation: 000244
- to stream PubMed, to step Checkpoint: 000244
- to stream Ncbi, to step Merge: 000964
- to stream Ncbi, to step Curation: 000964
- to stream Ncbi, to step Checkpoint: 000964
- to stream Main, to step Merge: 000960
- to stream Main, to step Curation: 000959
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Roles of Prion Protein in Virus Infections.</title><author><name sortKey="Sakaguchi, Suehiro" sort="Sakaguchi, Suehiro" uniqKey="Sakaguchi S" first="Suehiro" last="Sakaguchi">Suehiro Sakaguchi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University , Tokushima, Japan .</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University , Tokushima</wicri:regionArea><wicri:noRegion>Tokushima</wicri:noRegion></affiliation></author><author><name sortKey="Chida, Junji" sort="Chida, Junji" uniqKey="Chida J" first="Junji" last="Chida">Junji Chida</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University , Tokushima, Japan .</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University , Tokushima</wicri:regionArea><wicri:noRegion>Tokushima</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2018">2018</date><idno type="RBID">pubmed:30222366</idno><idno type="pmid">30222366</idno><idno type="doi">10.1089/dna.2018.4402</idno><idno type="wicri:Area/PubMed/Corpus">000244</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000244</idno><idno type="wicri:Area/PubMed/Curation">000244</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000244</idno><idno type="wicri:Area/PubMed/Checkpoint">000244</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000244</idno><idno type="wicri:Area/Ncbi/Merge">000964</idno><idno type="wicri:Area/Ncbi/Curation">000964</idno><idno type="wicri:Area/Ncbi/Checkpoint">000964</idno><idno type="wicri:Area/Main/Merge">000960</idno><idno type="wicri:Area/Main/Curation">000959</idno><idno type="wicri:Area/Main/Exploration">000959</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Roles of Prion Protein in Virus Infections.</title><author><name sortKey="Sakaguchi, Suehiro" sort="Sakaguchi, Suehiro" uniqKey="Sakaguchi S" first="Suehiro" last="Sakaguchi">Suehiro Sakaguchi</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University , Tokushima, Japan .</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University , Tokushima</wicri:regionArea><wicri:noRegion>Tokushima</wicri:noRegion></affiliation></author><author><name sortKey="Chida, Junji" sort="Chida, Junji" uniqKey="Chida J" first="Junji" last="Chida">Junji Chida</name><affiliation wicri:level="1"><nlm:affiliation>Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University , Tokushima, Japan .</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Division of Molecular Neurobiology, Institute for Enzyme Research (KOSOKEN), Tokushima University , Tokushima</wicri:regionArea><wicri:noRegion>Tokushima</wicri:noRegion></affiliation></author></analytic><series><title level="j">DNA and cell biology</title><idno type="eISSN">1557-7430</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Copper (immunology)</term><term>Copper (metabolism)</term><term>Enzyme Activation</term><term>Epithelial Cells (enzymology)</term><term>Epithelial Cells (immunology)</term><term>Epithelial Cells (virology)</term><term>Gene Expression Regulation (immunology)</term><term>Heat-Shock Proteins (genetics)</term><term>Heat-Shock Proteins (immunology)</term><term>Influenza A virus (pathogenicity)</term><term>Influenza A virus (physiology)</term><term>Lung (enzymology)</term><term>Lung (immunology)</term><term>Lung (virology)</term><term>Mice</term><term>Orthomyxoviridae Infections (enzymology)</term><term>Orthomyxoviridae Infections (genetics)</term><term>Orthomyxoviridae Infections (immunology)</term><term>Orthomyxoviridae Infections (virology)</term><term>Oxidative Stress</term><term>PrPC Proteins (genetics)</term><term>PrPC Proteins (immunology)</term><term>Protective Factors</term><term>Reactive Oxygen Species (immunology)</term><term>Reactive Oxygen Species (metabolism)</term><term>Superoxide Dismutase-1 (genetics)</term><term>Superoxide Dismutase-1 (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Activation enzymatique</term><term>Animaux</term><term>Cellules épithéliales (enzymologie)</term><term>Cellules épithéliales (immunologie)</term><term>Cellules épithéliales (virologie)</term><term>Cuivre (immunologie)</term><term>Cuivre (métabolisme)</term><term>Espèces réactives de l'oxygène (immunologie)</term><term>Espèces réactives de l'oxygène (métabolisme)</term><term>Facteurs de protection</term><term>Infections à Orthomyxoviridae (enzymologie)</term><term>Infections à Orthomyxoviridae (génétique)</term><term>Infections à Orthomyxoviridae (immunologie)</term><term>Infections à Orthomyxoviridae (virologie)</term><term>Poumon (enzymologie)</term><term>Poumon (immunologie)</term><term>Poumon (virologie)</term><term>Protéines PrPC (génétique)</term><term>Protéines PrPC (immunologie)</term><term>Protéines du choc thermique (génétique)</term><term>Protéines du choc thermique (immunologie)</term><term>Régulation de l'expression des gènes (immunologie)</term><term>Souris</term><term>Stress oxydatif</term><term>Superoxide dismutase-1 (génétique)</term><term>Superoxide dismutase-1 (immunologie)</term><term>Virus de la grippe A (pathogénicité)</term><term>Virus de la grippe A (physiologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Heat-Shock Proteins</term><term>PrPC Proteins</term><term>Superoxide Dismutase-1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Copper</term><term>Heat-Shock Proteins</term><term>PrPC Proteins</term><term>Reactive Oxygen Species</term><term>Superoxide Dismutase-1</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Copper</term><term>Reactive Oxygen Species</term></keywords><keywords scheme="MESH" qualifier="enzymologie" xml:lang="fr"><term>Cellules épithéliales</term><term>Infections à Orthomyxoviridae</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Epithelial Cells</term><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Infections à Orthomyxoviridae</term><term>Protéines PrPC</term><term>Protéines du choc thermique</term><term>Superoxide dismutase-1</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules épithéliales</term><term>Cuivre</term><term>Espèces réactives de l'oxygène</term><term>Infections à Orthomyxoviridae</term><term>Poumon</term><term>Protéines PrPC</term><term>Protéines du choc thermique</term><term>Régulation de l'expression des gènes</term><term>Superoxide dismutase-1</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Epithelial Cells</term><term>Gene Expression Regulation</term><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cuivre</term><term>Espèces réactives de l'oxygène</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Virus de la grippe A</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Influenza A virus</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Cellules épithéliales</term><term>Infections à Orthomyxoviridae</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Epithelial Cells</term><term>Lung</term><term>Orthomyxoviridae Infections</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Enzyme Activation</term><term>Mice</term><term>Oxidative Stress</term><term>Protective Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Activation enzymatique</term><term>Animaux</term><term>Facteurs de protection</term><term>Souris</term><term>Stress oxydatif</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The normal cellular prion protein, designated PrP<sup>C</sup>, is a membrane glycoprotein expressed most abundantly in brains, particularly by neurons, and to a lesser extent in non-neuronal tissues including lungs. Conformational conversion of PrP<sup>C</sup> into the amyloidogenic isoform is a key pathogenic event in prion diseases. We recently found that PrP<sup>C</sup> has a protective role against infection with influenza A viruses (IAVs) in mice by reducing reactive oxygen species in the lungs after infection with IAVs. The antioxidative activity of PrP<sup>C</sup> is probably attributable to its function to activate antioxidative enzyme Cu/Zn-superoxide dismutase, or SOD1, through regulating Cu content in lungs infected with IAVs. Oxidative stress could play a pivotal role in the pathogenesis of a wide range of viral infections. Here, we introduce our and others' studies on the role of PrP<sup>C</sup> in viral infections, and raise the attractive possibility that PrP<sup>C</sup> might be a novel target molecule for development of antioxidative therapeutics against not only IAV infection but also other viral infections.</div></front></TEI><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Sakaguchi, Suehiro" sort="Sakaguchi, Suehiro" uniqKey="Sakaguchi S" first="Suehiro" last="Sakaguchi">Suehiro Sakaguchi</name></noRegion><name sortKey="Chida, Junji" sort="Chida, Junji" uniqKey="Chida J" first="Junji" last="Chida">Junji Chida</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/StressCovidV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000959 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000959 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= StressCovidV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:30222366
|texte= Roles of Prion Protein in Virus Infections.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:30222366" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a StressCovidV1
| This area was generated with Dilib version V0.6.33. |  |